Martha's Vineyard
If you live in Boston, it is totally possible to make a trip to Martha's Vineyard a day trip. Mind, you may not want to leave after such a short period of time.
Portland, Maine
Just two hours north of Boston, Portland, Maine can be a great day trip for any foodie.
Sunday River
The ideal time to visit is the winter. One of the largest ski resorts in New England, you could spend more than a weekend getting to know all the trails.